New SweDeliver study gains international recognition
19 December 2021
An article published by Rosita Kneiszl Pettersson et al. at SweDeliver showing that permeation enhancers for oral absorption can induce membrane leakiness in a concentration dependent manner, has been selected as ACS Editors' Choice, a program highlighting a limited number of articles from more than 60 peer-reviewed journals.
In a current SweDeliver project, researchers at Uppsala University’s Faculty of pharmacy have conducted in silico studies of several permeation enhancers for oral absorption at different concentrations and with different charged states. Their results show that permeation enhancers can induce membrane leakiness in a concentration dependent manner – and the longer the chain of the negatively charged permeation enhancers, the greater the ability to disrupt the membrane.
“Our work shows how molecular dynamics simulations can be used to understand the molecular level interactions between a set of molecules that can be used to enhance permeability of orally administered drugs. In doing this, we also shed light on some methodological differences that it is important to be aware about,” states Rosita Kneiszl Pettersson, PhD Student at the Department of pharmacy.
The researchers, Rosita Kneiszl Pettersson, Shakhawath Hossain and Per Larsson, report their results in In silico-based experiments on mechanistic interactions between several intestinal permeation enhancers with a lipid bilayer model, an article published in scientific journal Molecular Pharmaceutics, and currently selected as ACS Editors' Choice® – a program that highlights a limited number of articles from the entire ACS portfolio of 64+ peer-reviewed journals.
“The selection of our article as ACS Editors' Choice was made by a panel of managing editors that are conversant with the current scientific literature and research, which of course is very inspiring. Our results confirm what has previously been reported in the literature, and a possible future step would be to extend these studies to only include the active substance itself, such as a peptide therapeutic,” says Rosita Kneiszl Pettersson.
- SweDeliver is a world leading research and competence centre in Drug Delivery with academic hub at Uppsala University's faculty of Pharmacy.
- The SweDeliver Oral Drug Delivery work package focus on mechanistic understanding and new in silico and in vitro models to better design advanced drug delivery systems fulfilling the requirements for absorption of macromolecules from the small intestine and small molecules from the colon.
- This work draws on the strong track record within in silico modelling and simulation, and in vitro assay development within the drug delivery and molecular pharmaceutics groups at Uppsala University.